Salmon DNA

Polynucleotides are special proteins that naturally occur in every living cell. Products used in aesthetics are derived from salmon DNA, as they are highly biocompatible. Allergic reactions and intolerances are extremely rare.

Polynucleotides act as powerful biostimulators, increasing skin hydration and gradually improving skin firmness and elasticity in the days and weeks after treatment. They are also effective in treating inflammation and scars. As they are based on biological material, their use is considered sustainable.

Biostimulators with polynucleotides stimulate skin renewal and improve overall skin structure. They bind water and provide protection against free radicals (oxygen compounds known to accelerate skin aging). When injected into the skin, they stimulate connective tissue regeneration. The skin produces more collagen and elastin and remodels itself, becoming visibly smoother and more elastic within a few weeks.

Polynucleotides are injected as a gel mixed with hyaluronic acid, which is why an initial effect is visible immediately after treatment. However, the full biostimulating effect develops over the following weeks.

The treatment is performed on an outpatient basis and usually involves no downtime. You can return to your daily activities immediately. Depending on the treatment area, the procedure takes approximately 20–40 minutes. Very fine needles are used, so the treatment may be slightly uncomfortable but is rarely painful. If desired, it can be performed under a very short twilight sedation.

Polynucleotides also provide excellent results for acne scars and dry, keratinized skin. Depending on the condition, one or more sessions at intervals of 2–4 weeks may be required.

Polynucleotide treatments are suitable even for younger skin from around the age of 30, helping to address early signs of aging or enlarged pores while improving overall skin quality. Polynucleotides act as effective antioxidants and help prevent premature skin aging.

They are also highly effective for older patients, sagging skin, and deeper wrinkles – especially in the cheek and chin area (marionette lines). The skin often appears fresher and rejuvenated within a few days. Skin firmness and contour improve, with further enhancement over the following weeks. Depending on the treatment goal, 2–3 sessions at intervals of a few weeks may be recommended.

For optimal results, we recommend an initial series of 4 treatments spaced 2–3 weeks apart, followed by maintenance sessions every 3 months. Unlike traditional fillers that deliver immediate results, polynucleotide treatments require some patience, with the best results visible after 2–3 months.

Polynucleotides are generally well tolerated. The most common side effects are related to the injection site, such as redness, swelling, or bruising. These are usually mild and resolve within a few days. More serious side effects, such as allergic reactions or infections, are very rare. All risks are thoroughly discussed during the consultation prior to treatment.

After treatment, you may cool the skin if needed. Avoid sports, sauna visits, and sunbeds for a few days. Consistent sun protection with SPF 50 is recommended, along with a hydrating serum.

Results are typically visible within a few weeks and can last up to 12 months. Polynucleotides interact with specific receptors in skin cells, promoting regeneration and the production of new collagen and elastin (biostimulation). This leads to smoother, firmer, and more youthful-looking skin.

Suitable combination treatments depend on the individual skin condition and desired outcome. Polynucleotide treatments are often combined with wrinkle injections, Morpheus8, ultrasound treatments, chemical peels, laser treatments, or Profhilo, as combination therapies often deliver the best results.

REJURAN is a high-quality skin regeneration treatment from Korea based on purified salmon DNA (polynucleotides). It supports natural skin cell repair, improves skin structure, and promotes a healthy, radiant complexion. REJURAN is considered one of the most researched polynucleotide products worldwide.

The key difference lies in the quality, purity, and stability of the polynucleotides. REJURAN uses highly purified, biocompatible polynucleotides from Korean research and medicine. Many other salmon DNA products contain less stable or less refined substances.

REJURAN was originally developed for medical tissue repair and has been successfully used in aesthetic dermatology for many years. Its specialized production ensures very high purity and excellent skin compatibility, allowing for particularly natural results.

While traditional skin boosters mainly contain hyaluronic acid for hydration, REJURAN uses polynucleotides that actively support skin regeneration and cellular repair. This not only hydrates the skin but also improves overall skin quality in the long term.

REJURAN originates from innovative Korean aesthetic medicine, which is considered a global trendsetter. What makes it unique is that it not only hydrates the skin but also activates natural skin regeneration, enabling particularly natural and long-lasting results.